PET Studies on Amino Acid Metabolism and Protein Synthesis

PET Studies on Amino Acid Metabolism and Protein Synthesis

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Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.min and later times up to 35 min following an i.v. pulse of [1-aquot;C]leucine, very little oa#39;-[1-aquot;C]ketoisocaproic acid (c. 0.7% of total brain aquot;C) can be detected in brain [8]. Reincorporation of label from aquot;CO, is negligible because of its dilution with unlabeled CO, produced by glucose ... Diagrammatic representation of the comprehensive model for behavior of [1-aquot;Cleucine and leucine in brain C, C#, CM, and Creanbsp;...

Title:PET Studies on Amino Acid Metabolism and Protein Synthesis
Author: B.M. Mazoyer, WD Heiss, D. Comar
Publisher:Springer Science & Business Media - 2012-12-06

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